| abstract |
A compound of formula (I) where: Does A represent a phenyl, heteroaryl or a cycloalkyl group of 4 to 8 carbon atoms? Q represents an oxygen atom or a -CH2 bond, do X, Y and Z represent atoms of carbon or nitrogen R1 and R2 are selected from: hydrogen, halogen, hydroxyl, cyano, oxo, -CF3, alkyl of 1 to 6 carbon atoms, alkyl, alkoxy of 1 to 6 carbon atoms, alkyl of 1 to 6 carbon atoms-O-alkyl of 1 to 6 carbon atoms, -O- alkyl of 1 to 6 carbon atoms-O-alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, -O- cycloalkyl of 3 to 8 carbon atoms - (CH2) m-SO2alkyl of 1 to 6 carbon atoms, benzyl, pyrazolyl, optionally substituted -CH2-triazolyl and -L-R12, where L represents a -CH2- and / or bond -CO- and / or -SO2-, and R12 represents a cycloalkyl of 3 to 8 carbon atoms or a group of formula (a), (b), (c), (c '), (d) or (e ): Does R3 represent an alkyl group of 1 to 10 carb atoms linear one that is optionally substituted R4 represents a hydrogen or halogen atom or a hydroxyl, cyano, alkyl of 1 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms, do R5 and R6 represent, independently of each other, a hydrogen or halogen atom or an alkyl group of 1 to 5 carbon atoms together form a cycloalkyl group of 3 to 6 carbon atoms, do R7 and R8 represent a hydrogen atom or an alkyl group of 1 to 5 atoms carbon, together they form a cycloalkyl group of 3 to 6 carbon atoms, do R9 and R10 represent a hydrogen atom or a hydroxyl group, -CO-alkyl of 1 to 6 carbon atoms or -COO-alkyl of 1 to 6 carbon atoms together form an alkylene chain of 2 to 3 carbon atoms R11 represents a hydrogen atom or an alkyl or cycloalkyl group. Procedures for its preparation, its use in therapeutic and pharmaceutical preparations that comprise them. |