| abstract |
This invention relates to a method for inhibiting the unwanted proliferation of an animal cell, the method comprises contacting an animal cell with a compound of the formula 1 and all salts, N-oxides, solvates, hydrates, crystalline forms or pharmaceutically acceptable geometric isomers and stereoisomers thereof: (see formula 1) wherein R1 is NR4R5, -N = CR19R21, OR6, G1 or G2; or C1-C8 alkyl, C2-C8 alkenyl, each optionally substituted; A is O, S or NR7; R2 is cyano, -NR8N = CR9R10 or NC (= O) OR30; or a 5 or 6 membered heteroaromatic ring, each ring or ring system optionally substituted; R3 is halogen, cyano, C1-C6 alkyl; J is C1-C6 alkyl or phenyl, optionally substituted; R4, R5, R6, R7, R8, R9, R10 R19, R21, R30, G1 and G2 are defined in the description. |