| abstract |
The invention provides methods for modulating, for example, antagonizing the activity of the Hedgehog signaling path. In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as loss of Ptc function, increased Hedgehog function, increased smoothed function or increased Gli function, which comprise contacting a cell with an amount sufficient of a compound of the invention (for example, a compound of Formula I). |