| abstract |
The present invention relates to a system for the directed administration of drug for administering a pharmacologically active substance to the central nervous system of a mammal through its blood brain barrier, wherein the system for directed administration of the drug comprises nanoparticles made of poly ( DL-lactide) (PLA) and / or poly (DL-lactide-co-glycolide) (PLGA), and at least one pharmacologically active substance that is absorbed, adsorbed and / or included in the nanoparticles, and that contains TPGS or comprises a coating of pluronic 188 surfactant deposited on the drug-loaded nanoparticles, as well as methods for producing the system for the directed administration of the drug and the use of the system for the directed administration of the drug to treat a disease or disorder of the central nervous system. |