| abstract |
The invention provides methods, nucleic acids, compositions and equipment for predicting a subject's response to a treatment with protein C or compound similar to activated protein C to identify subjects that have greater benefit from treatment with activated protein C; The method generally comprises determining the protein C pathway associated with genotype polymorphism genotypes of a subject in terms of one or more polymorphisms in these genes, comparing the determined genotype with known genotypes regarding the polymorphism corresponding to an improved response polymorphism. to identify potential subjects who have an inflammatory condition, who are more likely to benefit from treatment with protein C or compound similar to activated protein C and subsequent to recovery from treatment of the inflammatory condition; The invention also provides methods of treating such subjects with an anti-inflammatory agent or an anticoagulant agent based on the genotype of the subject. |