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filingDate 2006-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2008-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MX-2008008582-A
titleOfInvention MIMETIC PEPTIDES OF CARBOHYDRATES AND THEIR EMPLOYMENT IN PHARMACEUTICAL FORMULATIONS.
abstract The present invention is related to the pharmaceutical industry and biotechnology, more specifically to vaccine antigens applied against bacterial, viral, cancerous, or other diseases; development of formulations capable of protecting or elevating the protective spectrum of existing vaccines and extending it against different pathogens, using carbohydrates formed by repeated units of (? 2-8) N-substituted neuraminic acid as a target for the immune response; Peptides were isolated and identified as molecular mimetics of the capsular polysaccharide of Neisseria meningitidis serogroup B, consisting of repeated units of (? -28) N-acetylated neuraminic acid; the immunogenicity of the peptides was evaluated in animal biomodels, demonstrating their value as antibody inducing antigens capable of specifically recognizing N. meningitidis of serogroup B and showing bactericidal activity against it; The formulations resulting from this invention are applicable in the pharmaceutical industry as vaccine formulations for human use.
priorityDate 2005-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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