abstract |
Described are compounds of the chemical formula (I) or a pharmaceutically acceptable salt thereof, wherein M2 is N; X is a bond, alkylene, alkenylene, -O-, -CH2N (R12) -, -N (R12) CH2-, -N (R12) -, -NHC (O) -, -OCH2-, -CH2O-, or -S (O) 0-2- optionally substituted; and Y is - (CH2) 1-2-, -C (= O) -, -C (= NOR13) - or -SO0-2-; or M1 is N; M2 is N or CH; X is a bond, alkylene, alkenylene, -C (O) -, -NHC (O) -, -OC (O) - or -S (O) 1-2-; Y is - (CH2) 1-2, -C (= O) -, or -SO0-2; and when M2 is CH, Y is also Y is -O- or -C (= NOR13) -; Z is an optionally substituted bond or alkylene or alkenylene; U and W are CH, or one is CH and one is N; R1 is alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, optionally substituted heterocycloalkyl; R2 is alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or optionally substituted heterocycloalkyl; and the remaining variables are as defined in the specification; and compositions and methods for treating obesity, metabolic syndrome and a cognitive deficit disorder, alone or in combination with other agents. |