| abstract |
Compounds of the formula (see formula (I)) or a pharmaceutically acceptable salt or solvate thereof are described, wherein: M is CH or N; U and W are each CH, or one of U and W is CH and the other is N; X is a bond, alkylene, -C (O) -, C (N-OR5) -, -C (N-OR5) -CH (R6) -, -CH (R6) -C (N-OR5) -, -O-, -OCH2-, -CH2O- or -S (O) -0-2; and is -O-, - (CH2) 2-, -C (= O) -, -C (= NOR7) - or SO0-2-, Z is a bond, optionally substituted alkylene or alkylene interrupted by a heteroatom or group heterocyclic; R1 is alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl, or optionally substituted benzimidazolyl or a derivative thereof; R2 is alkyl, alkenyl aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or optionally substituted heterocycloalkyl, and the remaining variables are as defined in the specification; Compositions and methods for treating an airway response induced by allergy, congestion, diabetes, obesity, an obesity-related disorder, metabolic syndrome and a cognitive deficit disorder using said compounds, alone or in combination with other agents. |