| abstract |
The present invention relates to methods and compounds for modulating the complement system. In particular, compounds that inhibit complement activation are provided and compounds that promote complement activation are provided. The compounds are therapeutic by virtue of their effects on the complement system. Therefore, compounds that inhibit complement activation can be used for the treatment of reperfusion and ischemic disorders, including myocardial infarction and stroke, sepsis, autoimmune diseases, inflammatory diseases and diseases with an inflammatory component, which include Disease of Alzheimer's and other neurodegenerative disorders. |