http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2008002467-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e8092b9ec2a531edd1f796a5b8cb01e4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-439 |
| filingDate | 2006-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9a4bcd0ce3f2aac9db625f0ce592a41c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fd8131a8485a1514d7b1f7206957a38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91b47bc9daacced7aaf4008484a2a30b |
| publicationDate | 2008-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2008002467-A |
| titleOfInvention | DIAZATRICICLOALCANOS SUBSTITUTED WITH HETEROARILO, METHODS FOR THEIR PREPARATION AND USE OF THE SAME. |
| abstract | The present invention relates to amide and urea derivatives of heteroaryl substituted diazatricycloalkanes of formula (1): (see formula I) with the definition as set forth in the description, pharmaceutical compositions including the compounds, methods for preparing the compounds and treatment methods using the compounds; more specifically, treatment methods involve modulating the activity of the a7 subtype of nAChAs by administering one or more of the compounds to treat or prevent disorders mediated by the o7 subtype of nAChRs; diazatricycloalkanes typically consist of a 1-azabicyclooctane fused to a pyrrolidine ring; the heteroaryl substituent groups are 5- or 6-membered ring heteroaromatics, such as 3- pyridinyl and 5-pyrimidinyl portions, which are directly linked to the diazatricycloalkane; the secondary nitrogen in the pyrrolidine portion is substituted with an arylcarbonyl group (amide derivative) or an arylaminocarbonyl (N-arylcarbamoyl) group (urea derivative); the compounds are benefits in therapeutic applications that require a selective interaction of certain subtypes of nAChRs; that is, the compounds modulate the activity of certain subtypes of nAChRs, in particular the a7 subtype of nAChRs, and have no appreciable activity towards muscarinic receptors; Radiolabeled versions of the compounds can be used in diagnostic methods. |
| priorityDate | 2005-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.