http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2008002369-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d36a5393ba2d34a292205901b92681e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 |
| filingDate | 2006-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b940fff59f761d8e194679de330692f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f6f3ab46dd6e5c0e032d994533d9b8b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b710a3c29da221125891205c8bc594d7 |
| publicationDate | 2008-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2008002369-A |
| titleOfInvention | SHORT MOLECULES OF NUCLEIC ACIDS OF INTERFERENCE CHEMICALLY MODIFIED THAT ACT FROM MEDIATORS OF INTERFERENCE OF RIBONUCLEIC ACID. |
| abstract | The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to modulation of expression and / or genetic activity; The present invention also relates to compounds, compositions, and procedures related to traits, diseases and conditions that respond to the modulation of the expression and / or activity of genes involved in the routes of genetic expression or other cellular processes that act as mediators. of the maintenance or development of said traits, diseases and conditions; Specifically, the invention relates to double stranded nucleic acid molecules that include short nucleic acid molecules, such as short nucleic acid interference molecules (siNA), short interfering RNA (siRNA), double stranded RNA (dsRNA), micro -RNA (miRNA), and short hairpin RNA (shRNA) capable of acting as mediators of RNA interference (RNAi) against gene expression, including cocktails of said short nucleic acid molecules and formulations in lipid nanoparticles (LNP) ) of said short nucleic acid molecules; The present invention also relates to short nucleic acid molecules; such as siNA, siRNA, and others that can inhibit the function of endogenous RNA molecules, such as endogenous micro-RNA (miRNA) (eg, miRNA inhibitors) or endogenous short interference RNA (siRNA), (for example, siRNA inhibitors) or that can inhibit the function of RISC (for example, RISC inhibitors), to modulate gene expression by interfering with the regulatory function of said endogenous RNAs or of the proteins associated with said endogenous RNAs (for example, RISC) , which include cocktails of said short nucleic acid molecules and formulations in lipid nanoparticles (LNP) of said short nucleic acid molecules; said short nucleic acid molecules are useful, for example, to provide compositions for preventing, inhibiting, or reducing diseases, traits and conditions that are associated with the expression or genetic activity in a subject or organism. |
| priorityDate | 2005-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1884.