| abstract |
The invention is related to compounds with the general formula (see formula (I)) in which R 1 is lower alkyl substituted by halogen, or is aryl or heteroaryl, not substituted or substituted by halogen; R2 is heterocycloalkyl, aryl or heteroaryl, which is not substituted or substituted by one or more substituents, selected from the group consisting of halogen, lower alkyloxy, lower alkyl substituted by halogen, O-lower alkyl substituted by halogen or is substituted by C (O) -NR''2, (CR2) mC (O) -R ??, heteroaryl or S (O) 2-lower alkyl; R3 / R3, R4 / R4, and R5 / R5 are independently of each other hydrogen or fluorine, in which at least one of R4 / R4 or R5 / R5 is always fluorine; R ?? is aryl or hydroxy; R is hydrogen, cycloalkyl or is heterocycloalkyl; R is hydrogen or lower alkyl; M is 0, 1, 2 or 3; and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. It has been found that compounds with the general formula I are inhibitors of (-secretase and related compounds may be useful in the treatment of Alzheimer's disease or common cancers, which includes but is not limited to cervical carcinomas and carcinomas of breast and hematopoietic system neoplasms. |