| abstract |
The present invention relates to IL-12p40 binding proteins, particularly antibodies that bind human interleukin-12 (hlL-12) and / or human IL-23 (hlL-23). Specifically, the invention relates to antibodies that are chimeric, CDR-grafted and humanized antibodies. Preferred antibodies have high affinity for hlL-12 and / or hlL-23 and neutralize the activity of hlL-12 and / or hlL-23 in vitro and in vivo. An antibody of the invention can be a full length antibody or an antigen binding portion thereof. Methods for making and using the antibodies of the invention are also provided. The antibodies, or portions of antibodies of the invention, are useful for detecting hlL-12 and / or hlL-23 and for inhibiting the activity of hlL-12 and / or hlL-23, for example, in a human being subject suffering of a disorder where the activity of hlL-12 and / or hlL-23 is harmful. |