abstract |
Compounds of formula (IA) or (IB) are described, which are inhibitors of aurora kinase activity (see formula (IA) or (IB)): where -L1Y1- [CH2] -z- is a linker radical in wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4 alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S (= O) 2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is -N-, = CH- or = C (X1) - where X1 is cyano, cyclopropyl or halo; L2 linked radicals are as defined in the claims; R is a radical of the formula (X) or (Y) (see formula (X) or (Y)): where R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by a or more above intracellular carboxylesterase to a group of carboxylic acid; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl (C1-C6 alkyl), heteroaryl, heteroaryl (C1-C6 alkyl), - (C = O) R3, - (C = O) OR3, or - (C = O) NR3 wherein R3 is hydrogen or optionally substituted (C1-C6) alkyl, C3-C7 cycloalkyl, aryl, aryl (C1-C6 alkyl), heteroaryl, or heteroaryl (C1-C6 alkyl); R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a heterocyclic monocyclic ring of 5 or 6 atoms in the ring. |