| abstract |
Compounds of the formula: (I) or solvate thereof, wherein: R2 is an aryl group of 5 to 20 optionally substituted carbon atoms; R6 and R9 are independently selected from H, R, OH, OR, SH, SR, NH2, NHR, NRR ', nitro, Me3Sn and halo; wherein R and R 'are independently selected from alkyl groups of 1 to 12 optionally substituted carbon atoms, heterocyclyl of 3 to 20 carbon atoms and aryl of 5 to 20 carbon atoms, R7 is selected from H, R, OH, OR, SH, SR, NH2, NHR, NHRR ', nitro, Me3Sn and halo; R ?? it is an alkylene group of 3 to 12 carbon atoms, whose chain may be interrupted by one or more heteroatoms and / or aromatic rings; X is selected from O, S, or NH; z is 2 or 3; M is a pharmaceutically acceptable monovalent cation; R2 ,, R6 ,, R7 ,, R9 ,, X ?? and M ?? are selected from the same groups as R2, R6, R7, R9, X and M respectively, or M and M ?? together they can represent a pharmaceutically acceptable divalent cation. |