| abstract |
Compositions and methods for the treatment of diseases involving unwanted neovascularization (NV) are provided. The invention provides treatments that control NV through the selective inhibition of pro-angiogenic biochemical trajectories, including inhibition of gene expression of the VEGF path and localized inhibition in pathological NV tissues. Targeted tissue nanoparticle compositions comprising polymeric conjugates and nucleic acid molecules that induce RNA interference (RNAi) are provided. The nanoparticle compositions of the invention can be used alone or in combination with other therapeutic agents such as VEGF pathway antagonists. The compositions and methods can be used for the treatment of NV diseases such as cancer, eye disease, arthritis, and inflammatory diseases. |