http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2007012457-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a10dc651e733b8d5a1ec5684b812362 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-195 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2006-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_371123741e8388e9d51b5d96f7c17724 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20e2e8e027f91428dfe1465a3d94d35d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0c6b54362989fbf62488c7d9e7c8aa7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a964a6f22e6ad1bdb511f013e5ccceab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1cb64a3283ab6e0631d05b222352927 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9f8a8904e102c5aa5d617f00e3064672 |
| publicationDate | 2007-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2007012457-A |
| titleOfInvention | POLYMIXIN B ANALOGS FOR LTO DETOXIFICATION. |
| abstract | The invention relates to dimeros of SAEP II peptide that mimic polymyxin B, that is, in its ability to non-covalently bind lipopolysaccharide (LPS) of Gram-negative bacteria with high affinity, and therefore to detoxify LPS as does polymyxin. B. The dimeric structure is maintained by a pair of disulfide bonds that involve the two cysteine residues present in the peptide sequence, which does not exceed 17 amino acids and essentially comprises cationic and hydrophobic amino acid residues. In the dimeros of the invention, the peptides may have a parallel or anti-parallel orientation. As an exemplary subject, a number of the invention is constituted by a peptide of the formula NH2-Lys-Thr-Lys-Cysl-Lys-Phe-Leu-Leu-Leu-Cys2-COOH, either in a parallel dimeric form or antiparallel. The SAEP II dimers are useful for treating or preventing septic shock and related disorders generated by infection by Gram-negative bacteria. The invention also relates to LPS-peptide complexes in which LPS and the SAEP II dimers are non-covalently linked together. These complexes are useful as vaccination agents against infection by Gram-negative bacteria. |
| priorityDate | 2005-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.