abstract |
Heterocyclic substituted tricyclics of the formula (see formula I) or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture are described where ===== represents an optional double bond, the dotted line is optionally a bond or no link, resulting in a double bond or a single link, as allowed by the valence requirement and where An, En, Mn, Un, Gn, Jn, Kn, R9, R10, R11, R32, R33, B and Het are defined in the present invention and the remaining substituents are as defined in the specification, as well as pharmaceutical compositions containing them and a method for treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia. , heart failure, and cancer administering said compounds; combination therapy with other cardiovascular agents is also claimed. |