| abstract |
Formulations in nanoparticles of a benzodiazepine such as lorazepam, which does not require the presence of polyethylene glycol and propylene glycol as stabilizers, and methods for making and using said formulations are described; the formulations are particularly useful in aerosol and injectable dosage forms, and comprise benzodiazepine in nanoparticles, such as lorazepam, and at least one surface stabilizer; The formulations are useful in the treatment of epileptic state, treatment of irritable bowel syndrome, sleep induction, acute psychosis, and as a pre-anesthesia medication. |