http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2007008786-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6042509de7544921c96de43b9da1438 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2006-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5a93afd562f62ba01d63ad94ed08b6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9eae17eb610c6f32166c550c17d45f4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff770f22ae9267e437572b941dced47d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d3bd20e9322d9fb70610e5eefeaade3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1507f6578f1a43ce8b9e154c9b76408b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_276b709e39327b12d40acbde9571bd7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0c44aee58421b3694aa7625dc312702d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f37206a3fabf2f6412e5aa18a0d9e5e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6391e917aabcd0c519a165c77458d21c |
| publicationDate | 2007-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2007008786-A |
| titleOfInvention | NON-STEROID GLUCOCORTICOID RECEIVER MODULATORS. |
| abstract | The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof. In this formula, R1 is H or C1-4 alkyl; R2 is -C (O) R15 or -S (O) 2R15; R3 is H, C1-4 alkyl or -OR16; R4 is H, C1-4 alkyl or -OR16; R16 is H or -C (H) NOR16; R7 is H or halogen, cyano; C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, all three optionally substituted with OH, halogen or NH2; -C (H) NOR16, -OR16, -C (O) R16, or -C (O) R16; R8 is H, cyano, halogen, nitro; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or -O-C1-6 alkyl, all optionally substituted with amino, hydroxyl, or halogen; (hetero) aryl, optionally substituted with cyano, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy-C1-4 alkyl; -C (O) R18, -C (O) OR19, -C (O) NHR17, -NHC (O) R20, -C-C 1-4 alkyl-NOR21; -C (H) NOR16, or -NHS (O) 2R21; R9 is halogen, cyano or C1-4 alkyl optionally substituted with halogen; R10 is H or C1-4 alkyl; R11 is H; R12 is H, cyano or C1-4 alkyl; R13 is H, C1-4 alkyl, halogen or formyl; R14 is H, halogen, cyano, 1-4 alkyl, C2-6 alkenyl, C (O) R21 or (hetero) aryl; R15 is H; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, -O-C2-6 alkyl, -O-C2-6 alkenyl or -O-C2-6 alkynyl, all optionally substituted with one or more OH, halogen, cyano or (hetero) aryl, (hetero) aryl, optionally substituted with C1-4 alkyl, halogen, cyano, nitro, or amino, NH2, (di) -C 1-4 alkylamino, alkyl of C1-4-C1-4 alkoxyamine, C1-4 alkylthio-C1-4 alkyl or C1-4 alkoxy-C1-4 alkyl; R16 is H, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl; R17 is H, C1-6 alkyl, optionally substituted with halogen, C1-4 alkoxy or (hetero) aryl, optionally substituted with halogen, C1-4 alkyl or 1-25 4C alkoxy; C3-6 cycloalkyl or (hetero) aryl, optionally substituted with halogen, C1-4 alkyl or C1-4 alkoxy; R18 is H, NH2, C (O) R21 or C1-4 alkyl, optionally substituted with OH, halogen, cyano or -S-C1-4 alkyl; R19 is H or C1-6 alkyl, optionally substituted with OH or halogen; R20 is H, C1-6 alkyl or C2-6 alkenyl, both optionally substituted by halogen, O- C1-6 alkyl, (hetero) aryl, optionally substituted with C1-4 alkyl or halogen; C3-6 cycloalkyl; C1-3 alkoxy; C1-6 alkenyloxy; or (hetero) aryl, optionally substituted with C1-4 alkyl; NH2, -NH-C1-6 alkyl or -NH (hetero) aryl and R21 is H or C1-6 alkyl. The present invention also relates to pharmaceutical compositions comprising said compounds and the use of these derivatives to modulate glucocorticoid receptor activity. |
| priorityDate | 2005-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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