| abstract |
The invention provides compounds of Formula (I) (see Formula (I)): or salts, tautomers, N-oxides, or solvates thereof, wherein: R1 is selected from: (a) 2,6- dichlorophenyl; (b) 2,6-difluorophenyl; (c) a 2,3,6-trisubstituted phenyl group, wherein the substituents for the phenyl group are selected from fluorine, chlorine, methyl, and methoxy; (d) an R0 group, wherein R0 is a carbocyclic or heterocyclic group having 3 to 12 ring members; or a hydrocarbyl group of 1 to 8 carbon atoms optionally substituted; R2a and R2b are each hydrogen or methyl; and R3 is as defined in the claims. The compounds have activity as inhibitors of Cyclin Dependent Kinase (CDK) and Glycogen Syntase Kinase (GSK), kinases and which are useful in the treatment or prophylaxis of disease states or conditions mediated by kinases. |