http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MX-2007007837-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6042509de7544921c96de43b9da1438 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea32573deda329d908b33c6a921462f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec52cc0ebd2416cb4a516089ad14d242 |
| publicationDate | 2007-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MX-2007007837-A |
| titleOfInvention | ANTITROMBOTIC DUAL INHIBITORS THAT INCLUDE A BIOTINE WASTE. |
| abstract | The present invention relates to compounds of the oligosaccharide-A (I) separator of formula (I), wherein the oligosaccharide is a negatively charged oligosaccharide residue comprising two to twenty-five monosaccharide units, the charge being compensated for positively charged counterions, and wherein the oligosaccharide residue is derived from an oligosaccharide having anti-Xa activity (mediated by AT-III) per se: the separator is a flexible, essentially pharmacologically inactive, binding residue having a chain length of 10 to 70 atoms; A is the residue -CH [NH-SO2-R1] [CO-NR2-CH (4-benzamidine) -CO-NR3R4] wherein R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso) quinolinyl, tetrahydro (iso) quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, whose groups can be optionally substituted with one or more substitutes selected from (1-8C) alkyl or (1-8C) alkoxy; and wherein R2 and R3 are independently H or (1-8C) alkyl; R4 is (1-8C) alkyl or (3-8C) cycloalkyl; or R3 and R4 together with the nitrogen atom to which they join with a non-aromatic ring, consisting of (4-8) members that optionally contain another heteroatom, optionally replacing the ring with (1-8C) alkyl or SO2- ( 1-8C) alkyl; or a pharmaceutically acceptable salt thereof or a pro-drug or solvate thereof; wherein the compound of the formula I further comprises at least one covalent bond with a biotin residue or an analog thereof. The compounds of the invention have anti-thrombotic activity and can be used in the treatment or prevention of thrombosis or other thrombin-related diseases. The anti-thrombotic activity of the compound of this invention can be neutralized in emergency cases after administration of avidin, streptavidin and analogs thereof having high affinity to biotin. |
| priorityDate | 2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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