| abstract |
Novel glycopeptide antibiotic derivatives; these derivatives are represented by the formula (aglycone part of the antibiotic derivative of glycopeptides) - (Sac-NH) -RA [wherein (the aglycone part of the antibiotic derivative of glycopeptide) is the part formed by removing the sugar part from a known antibiotic derivative of glycopeptide; the part (Sac-NH) is an amino sugar part or a sugar chain part containing an amino sugar; and RA represents, for example, the formula X1-Ar1-XY-Ar2 (where X1, X2, and X3 each represents 1) an individual bond or 2) a heteroatom or a group containing a heteroatom selected from the group consisting of -N =, = N-, NR1-, -O-, etc .; And represents -NR2CO- or -CONR2 - (where R2 represents hydrogen or lower alkyl), etc.)], these derivatives have antibacterial activity against vancomycin resistant bacteria. |