| abstract |
An excellent LXR modulator is described. A compound represented by the following or similar general formula (I) is specifically described: (see formula (I)) [in the formula R1 represents -COR9 (wherein R9 represents alkyl, optionally substituted alkoxy or optionally substituted amino); R2 represents H, OH, alkoxy, optionally substituted amino or the like; R3 represents H, optionally substituted alkyl, cycloalkyl, optionally substituted alkoxy, optionally substituted amino, halogen, or the like; R4 and R5 represent H, optionally substituted alkyl, halogen, or the like; R6 and R7 respectively represent an H or alkyl; R8 represents -X2R10 [wherein R10 represents -COR11 (where R11 represents OH, optionally substituted alkoxy, optionally substituted amino, or the like), -SO2R12 (where R12 represents optionally substituted alkyl, optionally substituted amino, or the like), tetrazole -5-yl or the like; and X2 represents a single bond, an optionally substituted alkylene, or the like]; X1 represents -NH-, -O-, -S-, or the like; Y1 represents an optionally substituted phenyl or optionally substituted 5- or 6-membered aromatic heterocyclyl; and Y2 represents optionally substituted aryl, an optionally substituted heterocyclyl and the like]. |