| abstract |
The present invention relates to novel compounds useful as dipeptidyl peptidase IV (DPP-IV) inhibitors of formula (I) wherein Y is -S (O) m-CH2-, CHF, or -CF2; m is o, 1, or 2; X is a bond, C1-C5 alkyl (for example -CH2-), or -C (= O); the dotted line [----] in the carbocyclic ring represents an optional double bond; R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkylalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl ring, substituted unsubstituted heterocyclyl or substituted alkyl , -COOR3, CONR3R4, -OR3, -NR3R4, OR NR3COR3; R2 is hydrogen, cyano, COOH, or isostero of a carboxylic acid (such as SO3H, CONOH, B (OH) 2, PO3R3R4, SO2NR3R4, tetrazol-COOR3, CONR3R4, NR3COR4, or-COOCOR3). |