| abstract |
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of diseases mediated by cyan protein, including inflammation, cancer and related conditions. The compounds have the general Formula I, wherein Al, A2, A3, B, R1, R2, R3 and R4 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention. . |