abstract |
This invention relates to a new and convergent route to small molecule inhibitors of poly (ADP-ribose) polymerase, such as 8-fluoro-2- (4 - [(methylamino) methyl] phenyl (-1,3,4, 5- tetrahydro-6H-azepino [5,4,3-cd] indole-6-one, through a key coupling reaction of Sonogashira and indole formation promoted by Cul. |