| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e4b5702f58be45b7bf789a68955a7b7c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2875
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2005-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6161b245064f29a7b88200be7e8ff5e4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7b374276faa35d0267df545fd091431
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1436a1ff4e24e8bc4f57139160968e02 |
| publicationDate |
2008-01-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MX-2007003187-A |
| titleOfInvention |
MONOVALENT COMPOSITIONS FOR UNION TO CD40L AND METHODS OF USE. |
| abstract |
The invention relates to antibody polypeptides that bind monovalently to CD40L, antibody polypeptides that are monovalent for CD40L binding can inhibit CD40L activity while avoiding potential undesirable effects that may occur with antibodies capable of carry out divalent or multivalent CD40L union; in one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a particular variable domain of the immunoglobulin that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing the CD40 and / or CD40L activity, in another aspect, the anti-CD40L monovalent antibody polypeptide is a human antibody polypeptide; The invention further includes methods for antagonizing CD40 / CD40L interactions in an individual and methods for the treatment of diseases or disorders that include CD40 / CD40L interactions, methods including administration of a monovalent anti-CD40L antibody polypeptide to the individual. |
| priorityDate |
2004-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |