| abstract |
Compounds that can be used for the treatment or prevention of a condition associated with the proliferation of T cells or that is mediated by pro-inflammatory cytokines are of the formula (I): wherein R1 is CHR4-OR5 or CHR4-SR5, or aryl or heteroaryl optionally substituted with one or more R6 groups; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryl optionally substituted with R7; Each R6 is independently alkyl, CF3, OH, o-alkyl, OCO-alkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2-alkyl, CONH2, SOMe, SO2NH2, S-alkyl, CH2SO2-alkyl or OCON-alkyl; R7 is R8 or (CH2) nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON (R9) 2, NHCOR9, NHCO -aryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2) nOR9; (CH) nOR9, (CH2) nCOOR9 or (CH2) nCO-aryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof, including clenbuterol and atenolol. |