| abstract |
The present invention relates to the production of polyketides and other natural products and to libraries of individual novel compounds and compounds; therefore in one aspect the present invention provides 17-desmethylrapamycin and analogs thereof, methods for its production, including recombinant strains, and isolation and uses of the compounds of the invention; In a further aspect the present invention provides the use of 17-desmethylrapamycin and analogs thereof in the induction or maintenance of immunosuppression, stimulation of neuronal regeneration or treatment of cancer, B cell malignancies, fungal infections, rejection of transplant, disease and graft against host, autoimmune disorders, inflammation diseases, vascular disease and fibrotic diseases, and in the regulation of wound healing. |