| abstract |
The invention relates to compounds of the general formula (I), wherein: X1, X2, X3, X4, Z1, Z2, Z3, Z4 and Z5 independently represent each other a hydrogen or halogen atom or an alkyl group -C1-C6, cycloalkyl-C3-C7, fluoroalkyl-C1-C6, alkoxy-C1-C6, fluoroalkoxy-C1-C6, cyano, C (O) NR1R2, nitro, NR1R2, thioalkyl-C1-C6, -S ( O) -C1-C6 alkyl, -S (O) 2-C1-C6 alkyl, SO2NR1R2, NR3COR4, NR3SO2R5 or aryl; X5 represents a hydrogen or halogen atom or a C1-C6 alkyl, fluoroalkyl-C1-C6 group; R represents an optionally substituted 4-, 5-, 6- or 7-indolyl group; Y represents a hydrogen atom or a C1-C6 alkyl group, n is equal to 0, 1, 2, or 3; R1 and R2, independently of each other, represent a hydrogen atom or a C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C3 alkyl, or aryl group; or R1 and R2 together with the nitrogen atom that carries them form an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine, homopiperazine group, said group being optionally substituted with a C1-C6 alkyl group, C3-C7 cycloalkyl group, C3-C7 cycloalkyl-C1-C3 alkyl or aryl; R3 and R4 represent, independently of each other, a hydrogen atom or a C1-C6 alkyl or aryl group; R5 represents a C1-C6 alkyl or aryl group; in the form of acid or base addition salt, hydrate or solvate. The invention also relates to a method for preparing said compounds and their therapeutic use. |