| abstract |
The invention relates to amino-piperidine derivatives of the general formula (I) in which: Ra, Ra 'and R5 represent hydrogen atoms, or alkyl groups, R1 represents a hydrogen atom or an alkyl, cycloalkyl, heterocycloalkyl group or aryl, R2 represents a group of the formulas - (CH2) x- (CO) yY or - (CO) and- (CH2) xY, in which Y represents a hydrogen atom or a hydroxy, alkyl, cycloalkyl group, alkoxy, aryl, heteroaryl or -NR11R12, and being different from a hydrogen atom where x = y = 0, R3 represents 1 to 3 groups chosen from halogen atoms and alkyl, cycloalkyl, -OR, -NRR 'groups, -NR-CO-R ', -NR-CO-NRR', -NR-COOR ', -NO2, -CN and -COOR, and R4 is chosen from the groups of formulas (a), (b) and ( c), in which p = 0, 1, 2 or 3, m = 0, 1 or 2, and X represents an oxygen or sulfur atom or a chain -C (R6) (R7) - or -N ( R10) - :( Formulas (a), (b), (c)). Method of preparation and application in therapy. |