| abstract |
A pharmaceutical composition in powder form comprising (a) at least one water-soluble therapeutic agent selected from drugs that act as selective inhibitors of COX-2 and their drugs and prodrugs, for example, parecoxib sodium in a total therapeutically effective amount of approximately 30% to about 90% by weight, (b) a parenterally acceptable buffering agent in an amount of about 5% to about 60% by weight, and optionally (c) other parenterally acceptable excipient ingredients in a total amount not exceeding about 10% by weight of the composition. The composition is reconstitutable in a parenterally acceptable liquid solvent and forms a solution for injection. To make such a composition, a lyophilization process is used. |