| abstract |
The invention relates to novel products of formula (I) wherein p represents 0 to 2. R and R1 represent O or NH. R2 and R3 in particular represent hydrogen, alkyl, alkenyl. alkynyl, cycloalkyl, aryl and heteroaryl which are optionally substituted, or alternatively R2 and R3 form together with the carbon atom to which they are attached, a carbocyclic or heterocyclic radical, where these radicals may be optionally substituted. A1 represents a single bond, alkyl. allyl or propynyl. Y and Y1 in particular represent H, OCF3, S (O) nCF3, S (O) nAlk, SO2CHF2, SO2CF2CF3, -O-CHF2. -O-CH2-CF3, SF5 and SO2NR5R6, with R5 and R6 specially selected from hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, aryl and heteroaryl, which may be optionally substituted or alternatively R5 and R6 form together with N for which are attached, a heterocyclic radical. A2 represents A1, CO and SO2. B2 represents a heterocyclic radical optionally substituted with one or more substituents selected from the value for Y2. Y2 in particular represents hydrogen, halogen, hydroxy, cyano, alkyl, alkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -O-alkenyl, -O-alkynyl, -O-cycloalkyl, -S (O) n-alkyl, -S O) n-alkenyl, -S (O) n-alkynyl, -S (O) n-cycloalkyl, COOR13, -OCOR13, NR5R6, CONR5R6, S (O) n-NR5R6, -NR10-CO-R13, -NR10 -SO2-R13, NH-SO2-NR5R6, -NR10-CO-NR5R6, -NR10-CS-NR5R6 or -NR10-COOR13, where all of these radicals may be optionally substituted. n represents an integer from 0 to 2, where these products can be in any isomeric form or in salt form, as medicinal products. |