| abstract |
The present invention relates to a solid composition suitable for tissue adhesion, tissue closure, and haemostasis, which essentially consists of a) one carrier having at least one of the following physical properties: elastic modulus in the range of 5-100 N / cm, 1-10 mg / cm3 thick, chamber diameter greater than 0,75 mm and less than 4 mm and / or having an average chamber diameter below 3 mm and evenly spaced and fixed on said support, b) solid fi brinogen, ic) solid thrombin. The carrier is a biodegradable polymer such as polyhaluronic acid, polyoxylic acid, e.g. Lactic acid, glucolic acid, hydroxybutanoic acid, some cellulose, want n or collagen, such as a collagen sponge, e.g. A collagen sponge that is substantially neither composed of collagen fibers, nor I. fibrinogen and thrombin is preferably human, purified from a natural source, or transgenic or recombinant human fi brinogen and / or thrombin. In one preferred embodiment, the composition does not include any anti-fibrinolytic agent such as aprotic nin, ε-aminocapronic acid or α2-anti plasmin. |