| abstract |
The invention relates to medicine, in particular to the prevention and / or treatment of conditions related to the aberrant activity of fractalkine and monocyte chemoattractant proteins 1-4 (CCL2, CCL7, CCL8, CCL13), mainly in the treatment of alveolitis, pain syndrome, fever and high temperature, rheumatoid arthritis and other diseases using the compound 1- (2- (1H-imidazol-4-yl) ethyl) piperidin-2,6-dioneis or a pharmaceutically acceptable salt or solvate thereof. pharmaceutically acceptable, are extremely effective in inhibiting the activity of the enzyme glutaminylcyclase, involved, in particular, in the processes of post-translational modification of said cytokines. |