abstract |
The invention relates to the chemistry of natural compounds and medicinal chemistry, in particular to ent-kaurenoic acid derivatives containing a spiro-γ-lactam functional group, which have selective cytotoxic properties against human cancer cells and can be used as chemotherapeutic agents for the treatment oncological diseases. According to the invention, two derivatives of ent-kaurenoic acid with the following structural formulas are claimed: The claimed compounds possess selective cytotoxic activity against tumor cell lines Capan-1 (pancreatic adenocarcinoma), Hap-1 (chronic myeloid leukemia), HCT-116 (colorectal carcinoma) and NCI-H460 (lung carcinoma). |