| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e019980e0d3964666d42b84f16f7fe2a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1635
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1652
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-22 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 |
| filingDate |
2006-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b56cf192512abb19e6cbf4c71c227ac9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a847c1b9ddaa81172c6aaa853c4e973e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3aa469c582e8c6171cf9de2e2926ef6c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_887299eb4517c45d5b10f4fe7a165376 |
| publicationDate |
2013-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MD-4180-C1 |
| titleOfInvention |
A method of manufacturing pharmaceutical compositions containing rifaximin in the form of gastroresistant microspheres, compositions and their use for the treatment of inflammatory bowel diseases |
| abstract |
The invention relates to a method for the manufacture of pharmaceutical compositions containing rifaximin in the form of gastroresistant microbeads, to compositions based on the corresponding gastroresistant microbeads and to their use for treating inflammatory bowel diseases. The manufacturing method consists in spraying into a fluidized bed apparatus through a nozzle under a pressure of 1.0 ... 1.5 bar and at a speed of 150 ... 300 g / min of an aqueous suspension containing a gastroresistant polymer and excipients. At the same time, the apparatus supports active rifaximin in suspension together with a fluidity-increasing agent using a stream of air heated to a temperature of 50 ... 75 ° C and with an output flow rate of 450 ... 650 m3 / h. Rifaximin microgranules made according to the claimed method and pharmaceutical compositions for them the basis are gastroresistant due to the polymer coating insoluble at pH 1.5 ... 4.0 and soluble at pH 5.0 ... 7.7 and can be used in the manufacture of drugs for the effective treatment of inflammatory diseases intestinal tract, in particular Crohn's disease. |
| priorityDate |
2005-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |