| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-06 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-00 |
| filingDate |
2014-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75cce5bbad551af914795e27ba4e7cd3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3704ce3db277e4b7892bb38aa8be3b80
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b6cdf19836aedee030af8290ab878b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61ed8378a94624e6991d5c222526b0e7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_19836aa21f990394075aea1a112aaec8 |
| publicationDate |
2014-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MD-20140048-A2 |
| titleOfInvention |
Method for the synthesis of 3,4-dimethoxybicyclo ยข 4.2.0] octa-1,3,5-triene-7-carbonitrile and its use in the synthesis of ivabradine and its pharmaceutically acceptable acid addition salts |
| abstract |
The invention relates to a method for the synthesis of a nitrile of the formula (I): used as an intermediate in the synthesis of ivabradine. According to the claimed method, a compound of the formula (VII) is exposed to 1- (isocyanomethylsulfonyl) -4-methylbenzene (TosMIC) in the presence of a base in an organic solvent to obtain Also disclosed is a method for preparing compound (VII) through the interaction of 1,2-dibromo-4,5 dimethoxybenzene with 1,1-dialkoxyethene in the presence of an organometallic compound. A method for the synthesis of ivabradine, its pharmaceutically acceptable salts and its hydrates is characterized by that the compound of the formula (VII) is converted to the intermediate of the formula (I) according to the above-described method, which is further converted to ivabradine. |
| priorityDate |
2013-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |