| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6572ff5df928fd17340eb2a8cb6d8502 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-16 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-16 |
| filingDate |
2013-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba8d3ab1a010668ede2cb490eb640b65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_399ebef228f2b5b1fb185dca256b0417
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7b9a18756c6074b3fea68520088cc0f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e4f8ce06c6381361f6573dfd3ea5c04a |
| publicationDate |
2014-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
MD-20130092-A2 |
| titleOfInvention |
New process for the synthesis of 3- (2-bromo-4,5-dimethoxyphenyl) propannitrile and its application in the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid |
| abstract |
The present invention relates to a process for the synthesis of 3- (2-bromo-4,5-dimethoxyphenyl) propanenitrile of formula (I): which consists in subjecting a compound of formula (VIII): to a base in the presence of acetonitrile in an organic solvent to obtain a compound The invention also relates to a process for the synthesis of ivabradine, its pharmaceutically acceptable salts and hydrates using a compound of formula (I). This method provides a high percentage of the final product yield. |
| priorityDate |
2012-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |