| abstract |
The invention relates to novel solid pharmaceutical forms of agomelatine for oral administration. It describes a solid oral pharmaceutical composition, intended for systemic action, containing agomelatine or one of its hydrates, its complexes, cocrystals, crystalline forms, its addition salts with an acid or a pharmaceutically acceptable base, and one or more excipients selected from diluents, binders, flow agents, lubricants, coating agents, plasticizers, flavorings, counter-irritants and sweeteners, obtained by ensuring the slow release of the active ingredient and bioavailability absolutely greater than 25%. The suction preparation is in the form of a tablet, tablet or pill, which are obtained by extrusion of hot melt or injection into molds. Oral administration of agomelatine with the slow release of the active ingredient allows a significant increase in its bioavailability. . |