| abstract |
The invention relates to quinazoline compounds, which exhibit antiproliferative activity, such as antitumor activity, to the processes of preparation of these compounds, to the pharmaceutical compositions containing these compounds, and to their use for inhibiting the growth and proliferation of cells of higher organisms and microorganisms, such as bacteria, yeast and fungi. Preferred compounds of this invention are capable of inhibiting thymidylates synthase enzyme. |