http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MD-114-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b06591eadce0fde0a681bd8ef325ec7e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17 |
| filingDate | 1994-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7688aceb7431b06873aa356c3340c6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f93f08de3a6edb63956b1a8e7ed6657e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49ab5e7789ab7927b2073a6036426298 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4018e11ea7ed026843a0b29b0aa76254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc458ad892f70b7dc6f0d0d4acd1e1bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3152d2e3e31180bdf5586a0dee9ad786 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a084d6d333d545fc693a922afc68167 |
| publicationDate | 1995-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MD-114-C2 |
| titleOfInvention | The method of obtaining phenylalkylamines or their pharmacologically acceptable salts |
| abstract | The invention relates to phenylalkylamines, in particular to obtain compounds of the general formula C6 H6-CH2-CHR1-NHR2, wherein R1 is an n- or iso-C2-C8-alkyl, phenyl-C7-C10-alkyl, cyclo-C3 -C8-alkyl, phenyl; R 2 is a lower n- or isoalkyl, halogen-lower alkyl or lower hydroxyalkyl, C 1 -C 4 -alkoxypropylphenyl, C 3 -C 8 -cycloalkyl, R 1 and R 2 together containing C 5 -C 13, and when R 1 is ethyl, R 2 is not isobutyl; these compounds possessing antidepressant properties, which can be used in medicine. The object of the invention is to create substances of this class which are more active and have a low level of toxicity. The synthesis is carried out by reacting the amine of formula NH2-R2 with a ketone of formula C6H6-CH2-CR1-O with subsequent reduction by hydrogen, in the presence of palladium or Raney nickel, or using for hydrogenation the complex hydride of a metal, sodium dithionite, or aluminum amalgam. The final product is separated as a base or salt which can be used in pharmaceuticals. The new substances have a low toxicity, they are much more active than the known substances, without inhibiting monoamine oxidase. Claims: 1. Tables: 11. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MD-459-Z |
| priorityDate | 1986-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.