http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MA-38866-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| filingDate | 2014-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3008939871f8fb608b88473da4310e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fba317d29651221fff7ed070076715bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdceb1838662ca0c469e54c3245e0b60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebf5e2188b30b9b41a717e53ff519393 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d811b1a8279de15e4a41648373f8d328 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c8035790eac23a941bb82ea810d336a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a56e08e86fe720255a483fb731ffe17f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f5da41df2e0459388e6e457a1260570 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b25a2429315d864ee6892963ee7f79bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ce3f4bb5c2ea82eba32151451e78b88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40f2385c80ca2b0fb4716b422a1efc5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e5e5672d4d180aa74269174d97bede1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_df39075922bc5016d07b7dce19da3e3f |
| publicationDate | 2018-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | MA-38866-A3 |
| titleOfInvention | Bioconjugates of synthetic apelin polypeptides |
| abstract | The invention relates to bioconjugates comprising a synthetic polypeptide of formula (I ') or an amide, an ester or a salt thereof, wherein x1, x2, x3, x4, x5, x6, x7, x8, x9, x10, x11, x12 and x13 have the meaning indicated in the description and a moiety extending the half-life, the peptide and the half-life extending moiety being covalently bound or fused, optionally via a linker. The polypeptides are apj receptor agonists. The invention also relates to a method for producing said bioconjugates, as well as their therapeutic uses, in particular in the treatment or prevention of acute decompensated cardiac insufficiency (icda), chronic heart failure, pulmonary hypertension, atrial fibrillation, brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular disease, cardiomyopathy, cardiac fibrosis, arrhythmia, fluid retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, stroke, transient ischemic attacks, traumatic brain injury, amyotrophic lateral sclerosis, burns (including sunburn) and preeclampsia. The present invention further relates to a combination of pharmacologically active agents and a pharmaceutical composition. |
| priorityDate | 2013-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.