| abstract |
The present invention relates to a modified sulfamidase, a composition comprising a modified sulfamidase, as well as methods for preparing a modified sulfamidase and the therapeutic use of such a sulfonamide. In particular, the present invention relates to a modified sulfamidase comprising substantially no epitopes for glycan recognition receptors, thereby allowing the transport of said sulfamidase across the mammalian blood-brain barrier, said sulfamidase having catalytic activity. in the brain of said mammal. |