| abstract |
The present invention relates to novel inhibitors of indoleamine 2,3-dioxygenase-1 and / or indoleamine 2,3-dioxygenase-2 and / or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. The invention also relates to methods of preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (i) is useful in the treatment of diseases resulting from disruption of the kynurenine pathway. The compounds of formula (i) act by inhibiting the enzymatic activity or the expression of indoleamine 2,3-dioxygenase-1 and / or indoleamine 2,3-dioxygenase-2 and / or tryptophan 2, 3-dioxygenase. |