abstract |
The present invention relates to compounds of formula I wherein n, m, x, yl, r1, r2, r3, r4 and r5 are defined in the summary of the invention; which are capable of being both potent antagonists and estrogen receptor degrading agents. The invention further relates to a process for the preparation of the compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant activity. estrogen receptors. |