| abstract |
The present invention relates to novel pyrazolo-estriene and triazolo-estriene derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by an estrogen receptor such as hot flashes, drought. vaginal, osteopenia, osteoporosis, hyperlipidemia, loss of cognitive function, degenerative brain disease, cardiovascular disease, cerebrovascular disease, hormone-sensitive cancers and hyperplasia (in tissues including the breast , endometrium, and the cervix in women, and the prostate in men), endometriosis, uterine fibroids, osteoarthritis; and as contraceptive agents either alone or in combination with a progestogen or a progestogen antagonist. The compounds of the invention are selective estrogen receptor modulators. |