| abstract |
THIS INVENTION CONCERNS PYRROLIDIN-2-ONES REPRESENTED BY FORMULA (1) OR SALTS THEREOF, IN WHICH R1 REPRESENTS HYDROGEN OR A NITROGEN PROTECTIVE GROUP. The invention also relates to processes for their preparation and their use in the preparation of NEP inhibitors, more particularly for the preparation of an ethyl ester of N- (3-carboxyl-1-oxo-propyl) -butanoic acid ester. 4S) - (P-PHENYLPHENYLMETHYL) -4-AMINO- (2R) -METHYL OR A SALT THEREOF. |