| abstract |
THE PRESENT INVENTION CONCERNS MONO-SULFATE SALTS AND 2-CHLORO-4- [1- (4-FLUORO-PHENYL) -2,5-DIMETHYL-1H-IMIDAZOL-4-YETHYNYL] -PYRIDINE HEMI-SULPHATE , CRYSTALLINE AND AMORPHOUS FORMS THEREOF AND THEIR USE IN PHARMACEUTICAL PREPARATIONS. THE PRESENT COMPOUNDS ARE ACTIVE ON THE MGLUR5 RECEPTOR TO TREAT DISEASES ASSOCIATED WITH THIS RECEPTOR, SUCH AS ACUTE AND / OR CHRONIC NEUROLOGICAL DISORDERS, INCLUDING ANXIETY, OR TO TREAT CHRONIC AND ACUTE PAIN OR TO PROVIDE PROTECTION AGAINST INJURY HEPATICS, MEDICATION OR DISEASE-INDUCED INSUFFICIENCY, URINARY INCONTINENCE, OBESITY, FRAGILE X SYNDROME OR AUTISM. |